The Klira Special is a bespoke prescription formula with peak-potency actives that create cellular change for your skin.

It is applied once every evening and it replaces all other treatments in your routine. 

Each one is freshly formulated in our London-lab and delivered to your door within 48 hours.


Klira Specials combine the most effective actives with ingredients that work in synergy to maximise penetration in the most effective and nourishing way for your SkinSize™.

Ingredients are important but the precise ratio in which they are incorporated into the Klira Special is more important. When you bring all this together in one formula, as we have, it delivers maximum clinical results whilst feeling absolutely gorgeous on the skin.

This is a skin soother it is rich in phytosterols that calm and hydrate, and reduces transepidermal water loss form the skin. It also allows the transfer of active ingredients in a way that doesn’t cause irritation.
Azelaic acid works by exfoliating the skin, reducing the formation of comedones, as an anti-inflammatory and as an antioxidant. It is a powerhouse of an ingredient that can be used as a reliable treatment for acne, rosacea and pigmentation irregularities. It also works really well with ingredients like Retinoic Acid to help facilitate its absorption.
These are fatty acids made up from coconut oil or palm kernel oil and then combined with glycerin. Used to formulate and help facilitate delivery of ingredients, but actually with additional benefits in that it really hydrates the skin and is an emollient that works really well but never feels too heavy. It has antioxidant properties to neutralise free radical damage. It is also very low risk for causing skin sensitivity.
Ceramides can be used to rebuild and restore the protective skin barrier. They are particularly important when used in conjunction with other ingredients that form the lipid barrier of the skin. Cholesterol, Ceramides, Free fatty Acids. In the ratio 1:2:1 this mimics the natural skin barrier. These ingredients can be particularly helpful at certain times of life where there are hormonal changes, such as menopause.
Cholesterol is a molecule added to help support the skins natural barrier function and as an emollient. It is an essential structural component of cell membranes to maintain strength and fluidity. Cholesterol also functions to repair skin that has been stripped of its natural lipids by things like exfoliating or applying an aggressive anti-aging treatment. Due to its ability to strengthen the skin’s barrier, those with sensitive, and dry skin types will likely benefit most from cholesterol-containing creams.
This is one of the most effective hydrators of the skin. It makes the skin feel dewy, and is a wonderful feeling ingredient. It works as a humectant and attracts water in from the environment. As it is fairly small ingredient it can really penetrate to do the job it needs to do. It is really helpful for sensitive skin, and to protect against harsh environments or ingredients.
This is a molecule that is found naturally int the skin. HA is amazing at bonding with water and therefore plumping and repairing the skin barrier giving the skin a very hydrated look. As it plumps the skin cells it means that any appearance of wrinkles is reduce. It’s a huge molecule so it is not being absorbed into the deeper layers of the skin to do its job but rather when applied topically sits on the surface to plump the outer layer.
Collagen is a protein that when added to skincare is very useful for moisturising the skin. In the hydrolysed form, the peptides are thought to be able to tell the skin to make more collagen – though the evidence for this isn’t quite there yet. It is, however, a great moisturiser that has been shown to reduce the effects of skin-ageing such as dryness and wrinkling, predominantly by increasing water content in the stratum corneum.
This is usually a prescription only medication that is very effective at treating melasma, pigmentation irregularity due to inflammation or photodamage. The classic formulation with most evidence is 4% Hydroquinone but other concentrations are used. Like many of the prescription only medicines, this is more than just an “appearance “ of change: the treatment is actually working at the cellular level to reduce the production of pigment, so the effects take several weeks to realize. As the old skin exfoliates, the amount of pigment will be less, leading to a more even skin tone.
This is a really exciting ingredient that has been used in skincare increasingly over the last decade and is becoming the gold standard treatment for a number of conditions. Topical Ivermectin is an effective treatment for inflammatory papulopustular rosacea in adults. It has dual action as an anti-inflammatory and anti-parasitic effect. Positive therapeutic effects of Ivermectin due to its potential anti-inflammatory properties can be achieved in the other facial dermatoses such as perioral dermatitis, seborrheic dermatitis and acne vulgarisms.
This is a plant fat and is rich in antioxidants and fatty acids. It contained essential fatty acids ( Vitamin F) as well as Vitamin E, D and A. It is a fantastic hydrator of the skin and reduces transepidermal water loss. Fantastic for dry skin conditions and for windy dry season changes.
This is another emollient that has anti-inflammatory properties and supports the skin barrier. Squalene is a lipid that is naturally secreted by the sebaceous gland and is the molecule that stops our skin from drying out. It is predominantly plant sourced and is used to help soften the skin and support the skin when active ingredients are being introduced.

Tretinoin (retinoic acid) is the retinoid that has the best evidence behind it. This is the retinoid that is approved by the FDA for treatment of photodamage and acne. If your SkinSize dictates you could benefit from a retinoid then it is important to use one that will work. Retinol is a common cosmeceutical found on off-the shelf products that skincare companies know will be easier to use – but that is at the expense of effectiveness. Tretinoin is at least 20 times, and anything up to 100 times more powerful than retinol.

Tretinoin will change how a cell functions, it speeds up the turnover of older cells and encourages newer skin cells to divide more rapidly and build up the layers of the epidermis, thickening it through cell proliferation at the top level. It also increases the production of hyaluronic acid to keep the skin more plump. It can stimulate collagen production and importantly inhibit the breakdown of collagen. Tretinoin is also important to reduce inflammatory pathways in the skin that can contribute to acne and rosacea.

Klira Specials are formulated with a unique goal in mind: to allow everyone to get the benefit of the most effective and well-evidenced active ingredients for their skin.

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the specials

The Klira Special is our prescription formula. And we’re very proud of it because we believe it’s the very best formula of its kind. Each one is blended to ensure maximum absorption and efficacy, formulated with the essential trio of ‘ingredient’, ‘dose’ and ‘base’ : this is the power trilogy we live by.


We will deliver ingredients in increasing concentrations, and due to our unique base delivery system you will experience far less of the problems that are normally associated with starting powerful actives across every SkinSize™, and every skin colour.


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Recommending brands

All of the products we recommend in Klira routines are hand-picked by Dr Emma Craythorne, based on their proven ability to work with certain SkinSizes.

Our ethos is to put efficacy above all else, so we look for well-researched products that have been proven to the highest levels. 

Brands cannot pay to be featured in Klira routines, and we do not have any commercial obligations to the brands that we do feature. 

We use affiliate links to direct you to purchase the brands we recommend, meaning we do receive commission on sales made via Klira, but this a generic system that does not influence in any way the brands or products that are recommended.

We are always reviewing the newest evidence and brands to market, and Klira routine recommendations will change and evolve with not only the latest science, but what is right for your SkinSize depending on season, hormonal changes and environmental factors.